David M. Langenau, PhD

Massachusetts General Hospital

Academic Titles

Professor, Pathology, Harvard Medical School

Research Program Affiliation

Member, Sarcoma

Member, Leukemia

Research Abstract

The Langenau laboratory research focus is to uncover the mechanisms driving progression and relapse in pediatric tumors. Using novel, transgenic zebrafish models of pediatric sarcoma and leukemia that mimic human malignancy, we have undertaken studies to discover novel therapies by addition of drugs to the water and imaging tumor growth in live zebrafish. Moreover, we have utilized detailed imaging studies to visualize tumor cells in live animals and assess how cellular heterogeneity drives continued tumor growth. Capitalizing on insights gained from our zebrafish models of cancer, we are now extending our findings to human T-cell acute lymphoblastic leukemia and rhabdomyosarcoma.