Program

Prostate Cancer Program

The Prostate Cancer Program seeks to improve outcomes for all prostate cancer patients by bringing together a multidisciplinary team of investigators across the HCC consortium to catalyze and accelerate research leading to clinical benefit.

Recent, High-Impact Publications

  • Disability Status and Prostate Cancer Screening Among US Men Aged 55 to 69 Years.

    Nolazco JI, Iezzoni LI, Chen EC, Park ER, Wang W, Leapman MS, Alkhatib KY, Teoh JYC, Cole AP, Mossanen M, Lay AH, Bartels SJ, Kibel AS, Feldman AS, Chang SL

    Jama Network Open 2026; 9(8):e2627708.PubMed(opens in new window)
  • Perioperative Apalutamide in High-Risk Localized Prostate Cancer.

    Taplin ME, Gleave M, Shore ND, Lopez-Gitlitz A, Kretschmer A, Efstathiou E, Nguyen PL, Damião R, Kamoto T, Ross A, Briganti A, Hadaschik BA, Heidenreich A, Juárez Soto Á, Ye H, Gotto G, Rooney B, Tian SK, Wetherhold L, Miladinovic B, McCarthy SA, Evans CP, Kibel AS,

    The New England journal of medicine 2026.PubMed(opens in new window)
  • Pain and health-related quality-of-life outcomes with darolutamide in metastatic hormone-sensitive prostate cancer (ARANOTE): secondary and exploratory analyses of a multicentre, randomised, placebo-controlled, phase 3 trial.

    Morgans AK, Haresh KP, Jievaltas M, Olmos D, Shore ND, Vjaters E, Xing N, Mohamed AF, Littleton N, Srinivasan S, Verholen F, Saad F

    The Lancet. Oncology 2026; 27(5):614-624.PubMed(opens in new window)
  • A conserved hormonal signalling-H2A.Z axis rapidly reorganizes 3D chromatin interactions in adipocyte thermogenesis.

    Zhang Y, Zheng R, Tsuji T, Wang CH, Liu XY, Xing YH, Darcy J, Lynes MD, Lundh M, Arianti R, Győry F, Dong R, Emanuelli B, Johnstone SE, Rivera MN, Kristóf E, Kahn CR, Chen K, Tseng YH

    Nature Metabolism 2026.PubMed(opens in new window)
  • A dual role of EZH2 in regulating A-to-I RNA editing and mRNA stability through ADAR.

    Yi Y, Li Y, Wang R, Yu X, Liu Q, Yum C, Zhang Y, Qiao Y, Szczepanski A, Wu S, Li Q, Fazli L, Shen J, Wang X, Li X, Mu P, Schaeffer EM, Hundley HA, Niu H, Chinnaiyan AM, Wang L, Shi J, Jin J, Dong X, Zhao W, Chen K, Cao Q

    Nature Communications 2026.PubMed(opens in new window)
  • Crosstalk between EZH2 and DNA methylation mediates neuroendocrine prostate cancer lineage plasticity.

    Singh R, Venkadakrishnan VB, Imada E, Yamada Y, Brady NJ, Dunmore KE, Garner R, Booker MA, Hanratty B, Haffner MC, Tolstorukov MY, Marchionni L, Robinson BD, Rickman DS, Beltran H

    Nature Communications 2026.PubMed(opens in new window)
  • FOXJ1 mediates taxane resistance through regulation of microtubule dynamics.

    Xie F, Gjyrezi A, Fein D, Labaf M, Poluben L, Ersoy-Fazlioglu B, Dennehy CM, Voznesensky O, Gad A, Corey E, Varkaris A, Einstein DJ, Bhatt RS, Giannakakou P, Balk SP

    Nature Communications 2026.PubMed(opens in new window)
  • cGAS restricts PARP1-mediated microhomology-mediated end joining by suppressing poly-ADP-ribosylation.

    Yang H, Gao B, Wu B, Li W, Zhu X, Phoon L, Luo J, Gui F, Zhao W, Jia L, Lan L

    Cell death and differentiation 2025.PubMed(opens in new window)
  • Quantitative functional profiling of ERCC2 mutations deciphers cisplatin sensitivity in bladder cancer.

    Börcsök J, Gopaul D, Devesa-Serrano D, Mooser C, Jonsson N, Cagiada M, Stormoen DR, Ataya MN, Guercio BJ, Kaimakliotis HZ, Iyer G, Lindorff-Larsen K, Dyrskjøt L, Mouw KW, Szallasi Z, Sørensen CS

    The Journal of clinical investigation 2025; 135(16).PubMed(opens in new window)
  • Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer.

    Mizuno K, Ku SY, Venkadakrishnan VB, Bakht MK, Sigouros M, Chan J, Trigos A, Driskill JH, Manohar J, King A, Presser AG, Kim MJ, Tewari AK, Long HW, Quigley D, Choueiri TK, Balk S, Hill S, Mosquera JM, Einstein D, Sandhu S, Taplin ME, Beltran H

    Nature Communications 2025; 16(1):5543.PubMed(opens in new window)
  • BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress.

    Varkaris A, Wang K, Nouri M, Kozlova N, Schmidt DR, Stavridi A, Arai S, Ambrosio N, Poluben L, Jimenez-Vacas JM, Westaby D, Carmichael J, Xie F, Figueiredo I, Buroni L, Neeb A, Gurel B, Chevalier N, Brown L, Voznesensky O, Chen SY, Russo JW, Yuan X, Juric D, Beltran H, De Bono JS, Vander Heiden MG, Einstein DJ, Muranen T, Corey E, Sharp A, Balk SP

    Nature Communications 2025; 16(1):4931.PubMed(opens in new window)
  • Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation.

    Teng M, Guo J, Xu X, Ci X, Mo Y, Kohen Y, Ni Z, Chen S, Guo WY, Bakht M, Ku S, Sigouros M, Luo W, Macarios CM, Xia Z, Chen M, Ul Haq S, Yang W, Berlin A, van der Kwast T, Ellis L, Zoubeidi A, Zheng G, Ming J, Wang Y, Cui H, Lok BH, Raught B, Beltran H, Qin J, He HH

Prostate Cancer Program Members

Leaders

Members