Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities.
Linville RM, James BT, Galani K, Ho LL, Shin JH, Oliver E, Fass SB, Cameron JC, Fitzwalter BE, Bock R, Murray EM, Louçã M, Oke O, Wang C, Engelberg-Cook E, DeTure M, Farrell V, Pineda SS, Sathitloetsakun S, Liang X, Madras B, Dickson DW, Mash DC, Turecki G, Wheeler VC, Alvarez VA, Gabuzda D, Kellis M, Heiman M
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4.
Chu C, Zheng S, Mitchell N, Li Z, Zhang X, Wu X, Zhang T, Dang F, Michowski W, Kolodziejczyk A, Xu ML, Kotowski KW, Yang Z, Martinez-Alonso D, Paulo J, Sheng J, Kirby JA, Groezinger F, Zhou Y, He M, Ito Y, Gulvady AC, Cole MI, Foidart P, Nishida J, Ning X, Sharma S, Suski JM, Fassl A, Zhou Y, Geng Y, Wei W, Gygi SP, Polyak K, Wucherpfennig KW, Sicinski P
TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation.
Chi X, Wang CH, Parisotto YF, Nyberg WA, Cabric V, Gelineau A, Cao Y, Owen DL, Ambjörnsson J, Mathis D, Eyquem J, Brown CC, Benoist C
Non-genotoxic transplantation and in vivo selection through epitope editing.
Casirati G, Cosentino A, Freschi M, Zeng J, Mucci A, Levesque S, Neri N, Drago E, Carzaniga V, Romano F, Katta V, Matsubara A, Li Y, Mahmoud MS, Chávez-Navarro M, Brendel C, Manis JP, Tsai S, Pellin D, Bauer D, Genovese P
Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis.
Tang J, Pernes G, Nakagaki B, Tran N, Bokor L, Prenen F, Yi M, Robertson AE, Cronin R, Sarmini M, Pierscianowski J, Roberts V, Ryback BA, Novina CD, Auclair K, Xiao H, Mills EL
Genomic correlates of clinical CAR T cell activity.
Leick MB, Sun B, Birocchi F, Gallagher KME, Bratt A, Han S, Martin G, Silva HJ, Larson RC, Chinsky TM, Chu H, Reilly CR, Kann MC, Choi BD, Camp S, Gillani R, Phillips M, Kienka T, Bailey SR, Graham CE, Jan M, Moore NS, Horick N, Budka J, Filosto S, Williams CM, Hosseini Rad A, Shen RR, Van Allen E, AlDubayan S, Maus MV
The CARM1 epigenetic enzyme inhibits cross-presenting dendritic cell function in cancer immunity.
Zhang X, Xirenayi S, Zhao Y, Wang W, Han Y, Sobral M, Kang S, Zhang C, Barlow GL, Pyrdol J, Cho JW, Huang K, Ning X, Hemberg M, Yuan GC, Van Allen EM, Mooney DJ, Wucherpfennig KW
Inflammatory cytokines induce new cancer dependencies.
Cheruiyot CK, Kim SY, Dubrot J, Lane-Reticker SK, Miranda A, Kammula AV, Perera JJ, Du PP, Chuong CL, Fetterman RA, Knudsen NH, Jiang A, Suermondt JSMT, Pass LF, Fu C, Wu MJ, Shi L, Anderson S, Muscato AJ, Avila OI, Kohnle IC, Kessler EA, Pope HW, Noel SG, Olander KE, Chung J, Colvin KJ, Bardeesy N, Yates KB, Manguso RT
Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.
Ghannam JY, Bryan J, Weiss J, Kovarsky D, Merrell D, Messer C, Schlueter-Kuck K, Fell GG, Lim-Fat MJ, Youssef G, Rahman R, Qin L, Young GS, Janes JT, Van Orden M, Pfaff KL, Gans A, Lin ES, Huang RY, Danysh BP, Parida L, Li S, Wen PY, Chiocca EA, Neuberg D, Ligon KL, Tirosh I, Reardon DA, Getz G, Wu CJ
Efficacy and safety of durcabtagene autoleucel in a phase 1 trial for patients with relapsed/refractory multiple myeloma.
Sperling AS, Derman BA, Nikiforow S, Alonso A, Ikegawa S, Orwitz N, Quinn DS, Pearson D, Bu D, Milanez-Almeida P, Mataraza J, Nadeem O, Liegel J, D'Souza A, Charles A, Credi M, Ritz J, Jakubowiak AJ, De Vita S, Munshi NC
Ficerafusp Alfa (BCA101) With Pembrolizumab for Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Two-Year Results of an Expansion Cohort of a Phase I/Ib Trial.
Hanna GJ, Zandberg DP, Wong DJ, Sherman E, Sacco AG, Yilmaz E, Hernando-Calvo A, Reiners RD, Bohr D, Salazar RL, O'Connell BC, Raben D, Schulten J, Chung CH, Kaczmar J
Lipid Nanoparticle-encapsulated mRNA-2752 Encoding Human OX40L, IL-23, and IL-36γ Plus Durvalumab Induces an Immunostimulatory Effect Within the Tumor Microenvironment in Patients with Advanced Solid Tumors.
Sweis RF, Long GV, Daud A, Stemmer SM, Jimeno A, Perets R, Kummar S, Patel MR, Khattak A, Abadier M, Van L, Guo R, Do KT, Sullivan RJ
