Structural basis of GSDME pore formation and its regulation by S-palmitoylation.
Du G, Ehrmann JF, Lieberman J, Wu H
AI-enhanced adaptive virtual screening of large libraries for ligand discovery.
Cecchini D, Nigam A, Tang M, Reis J, Koop M, Gottinger A, Nicoll CR, Wang Y, Jayaraj A, Çınaroglu SS, Törner R, Malets Y, Gehev M, Padmanabha Das KM, Churion K, Kim J, Thomas N, Li Y, Seo HS, Dhe-Paganon S, Secker C, Haddadnia M, Hasson A, Li M, Kumar A, Levin-Konigsberg R, Choi EB, Shapiro GI, Cox H, Sebastian L, Braithwaite C, Bashyal P, Radchenko DS, Kumar A, Yang L, Aquilanti PY, Gabb H, Alhossary A, O'Neill E, Wagner G, Aspuru-Guzik A, Moroz YS, Kalodimos CG, Fackeldey K, Schuetz JD, Mattevi A, Arthanari H, Gorgulla C
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4.
Chu C, Zheng S, Mitchell N, Li Z, Zhang X, Wu X, Zhang T, Dang F, Michowski W, Kolodziejczyk A, Xu ML, Kotowski KW, Yang Z, Martinez-Alonso D, Paulo J, Sheng J, Kirby JA, Groezinger F, Zhou Y, He M, Ito Y, Gulvady AC, Cole MI, Foidart P, Nishida J, Ning X, Sharma S, Suski JM, Fassl A, Zhou Y, Geng Y, Wei W, Gygi SP, Polyak K, Wucherpfennig KW, Sicinski P
Defective microhomology-mediated end joining in -deficient tumors.
Zhu G, Asada S, Nguyen H, Hirohashi Y, Sun L, Saravanapavan A, Rahmani E, Hrynashka M, Mukkavalli S, Batish M, Shapiro GI, D'Andrea AD
Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.
Shettigar M, Moulière S, Isenegger L, DeVine AL, Gstalder C, Koduri V, Doench JG, Ksander B, Garcia-Marcos M, Kaelin WG, Haq R
Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth in Drosophila.
Huang K, Miao T, Chen Y, Dantas E, Sanford J, Asara JM, Moon SJ, Hu Y, Wang K, Han M, Goncalves M, Perrimon N
DMXL1 promotes recruitment of V1-ATPase to lysosomes upon TRPML1 activation.
Lee C, Eldridge MJG, Gonzalez-Lozano MA, Bresnahan T, Niday Z, Del Camino D, Fu T, Paulo JA, Moran MM, Helaine S, Harper JW
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion.
Glassman CR, Baek K, Hou G, Zeng Q, Nardone C, Juergens KB, Fujimura E, O'Leary CN, Li MZ, Paulo JA, Fischer ES, Ding S, Harper JW, Elledge SJ
DCAF11-dependent molecular glue degrader activated by glutathionylation.
Yoon H, Wachter F, Barrett KA, Jin C, Rodríguez-Pöhnlein A, Rutter JC, Lumpkin RJ, Metivier RJ, Donovan KA, Baek K, Jiang Y, Lee M, Kalis RW, Che J, Xiong Y, Fischer ES, Ebert BL
An AI-enabled structural atlas decodes kinase specificity across the human proteome.
Vanderwall DR, Huttlin EL, Mintseris J, Yaron-Barir TM, Johnson JL, Dong KD, Bott AJ, He Y, Schroeter CB, Frere GA, Uduman M, Lee H, Landry S, Beausoleil SA, Paulo JA, Cantley LC, Gygi SP
Disruption of microhomology-mediated end joining in Ewing sarcoma.
Asada S, Zhu G, Abeykoon JP, Tanaka Y, Nguyen H, Hirohashi Y, Iyer DR, Ashton NW, Mukkavalli S, Velazquez M, Jiang L, Del Busso M, Thangaiah JJ, Robinson SI, Parmar K, Van Allen EM, Gillani R, Shapiro GI, D'Andrea AD
A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.
Fujimura E, O'Leary CN, Li MZ, Roberts RA, Glassman CR, Paulo JA, Jiang H, Abdelfattah NS, Wooten EC, Mirman Z, Harper JW, Cole PA, Elledge SJ
