Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia.
Fathi AT, Perl AE, Fell GG, Jonas BA, Ragon BK, Mims AS, Borate U, Mannis GN, Quillen K, Stahl M, Aubrey BJ, Koller P, Artz AS, Al Malki MM, Stein AS, Marcucci G, Peters MLB, Graubert TA, Westervelt P, Amrein PC, Hock HR, Brunner AM, Hobbs G, Narayan R, Lee MH, Miller PG, Watson AL, Hao R, Marola AC, Lombardi-Story J, Dhaver S, Grunwald MR, Chen YB, Weinstock MJ, Matthews AH, McGovern I, Wood BL, Hourigan CS, Neuberg DS, El-Jawahri A, Aldoss I
Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4.
Chu C, Zheng S, Mitchell N, Li Z, Zhang X, Wu X, Zhang T, Dang F, Michowski W, Kolodziejczyk A, Xu ML, Kotowski KW, Yang Z, Martinez-Alonso D, Paulo J, Sheng J, Kirby JA, Groezinger F, Zhou Y, He M, Ito Y, Gulvady AC, Cole MI, Foidart P, Nishida J, Ning X, Sharma S, Suski JM, Fassl A, Zhou Y, Geng Y, Wei W, Gygi SP, Polyak K, Wucherpfennig KW, Sicinski P
Non-genotoxic transplantation and in vivo selection through epitope editing.
Casirati G, Cosentino A, Freschi M, Zeng J, Mucci A, Levesque S, Neri N, Drago E, Carzaniga V, Romano F, Katta V, Matsubara A, Li Y, Mahmoud MS, Chávez-Navarro M, Brendel C, Manis JP, Tsai S, Pellin D, Bauer D, Genovese P
DCAF11-dependent molecular glue degrader activated by glutathionylation.
Yoon H, Wachter F, Barrett KA, Jin C, Rodríguez-Pöhnlein A, Rutter JC, Lumpkin RJ, Metivier RJ, Donovan KA, Baek K, Jiang Y, Lee M, Kalis RW, Che J, Xiong Y, Fischer ES, Ebert BL
MYOD1 mutation drives cancer stem cell pathways and therapy-resistance in spindle cell/sclerosing rhabdomyosarcoma.
Wei Y, Corchete Sánchez LA, Mathavarajah S, Antelo D, Wang S, Lee J, Weissman AD, Kannambadi DD, Qin Q, Danielli SG, Quantin EJ, Eng TC, Veloso A, Wang Y, Neilsen GP, Yan C, Yang VS, Patel AG, Koo SC, Odeniyide P, Pratilas CA, Rivera MN, Rheinbay E, Langenau DM
Tumor transcriptional state predicts survival in immune-checkpoint-blockade-treated glioblastoma.
Ghannam JY, Bryan J, Weiss J, Kovarsky D, Merrell D, Messer C, Schlueter-Kuck K, Fell GG, Lim-Fat MJ, Youssef G, Rahman R, Qin L, Young GS, Janes JT, Van Orden M, Pfaff KL, Gans A, Lin ES, Huang RY, Danysh BP, Parida L, Li S, Wen PY, Chiocca EA, Neuberg D, Ligon KL, Tirosh I, Reardon DA, Getz G, Wu CJ
Copper depletion boosts CNS leukemia therapy by inhibiting nucleotide synthesis through impairment of mitochondrial complex IV activity.
Wong AYL, Myers JW, Prakash G, Ma A, Brook JR, Petrova B, Bulut B, White R, Merz C, de Souza M, Maynard AG, Wang P, Yu A, Pohl NK, Weitman M, Silverman LB, Stegmaier K, Churchman LS, Cole PD, Brady DC, Kanarek N
Dual BCL-xL and BCL-2 Inhibition for Advanced Myeloid Neoplasms: A phase 1 dose-escalation study of Navitoclax, Venetoclax, and Decitabine.
Chen EC, Liu Y, Bell HL, Ryan J, Wu J, Minihane EJ, Luskin MR, Winer ES, Vedula R, Volpe V, Stahl M, Roberts D, Galinsky I, Gerard M, Hersch M, Lee J, Neuberg D, Stone RM, DeAngelo DJ, Letai A, Lane AA, Garcia JS
Genetic variation reveals a homeotic long noncoding RNA that modulates human hematopoietic stem cells.
Lyu P, Agarwal G, Guo CJ, Sychla A, Bourgeois W, Ye T, Weng C, Antoszewski M, Joubran S, Caulier A, Poeschla M, Armstrong SA, Rouskin S, Sankaran VG
CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials.
Bourgeois W, Rice HE, Wenge DV, Perner F, Yue H, Regalado BD, Wan G, Schroeder JC, Sommerschield A, Hatton C, Singh S, Singh S, Bijpuria S, McKeever BM, Miller WH, Safer JF, Iqbal S, Perry JA, Fischer ES, Doench JG, McGeehan GM, Cutler JA, Armstrong SA
Mutant ribosomal protein RPS15 drives B cell malignancy through oxidative stress and genomic instability.
Gutierrez C, Kwok M, Ruthen N, Waddicor P, Curran C, Ouspenskaia T, Fu D, Smalec B, Sedor S, Knisbacher BA, Biran A, Nagler A, Garbicz F, Sewastianik T, Penailillo J, Lucas F, Yin S, Liani A, Chen S, Lazarian G, Witten E, Dangle N, Brunsting EL, Zheng M, Lin ES, Lee MJ, Wells B, Pomerance L, Hernández-Sánchez M, Li S, Lin Z, Al'Khafaji A, Wang L, Thakurela S, Livak KJ, Neuberg D, Cymbalista F, Getz G, Regev A, Churchman S, Ten Hacken E, Carrasco R, Shao S, Wu CJ
Bnip3lb-driven mitophagy maintains fate of the embryonic hematopoietic stem cell pool.
Meader E, Walcheck MT, Leder MR, Delaney P, Falchetti M, Jing R, Li C, Kambli NK, Wrighton PJ, Sugden WW, Najia MA, Oderberg IM, Taylor VM, LeBlanc ZC, Quenzer ED, Lim SE, Schlaeger T, Daley GQ, Goessling W, North TE
