Program

Cancer Risk, Prevention, and Early Detection Program

The mission of the Cancer Risk, Prevention, and Early Detection (CaRPED) Program is to decrease the burden of cancer by (a) focusing a broad array of research around the critical period of cancer initiation and early growth, and (b) devising clinically effective strategies to intercept this process among people at risk.

Recent, High-Impact Publications

  • Population-based genomic detection of childhood cancer predisposition using newborn dried blood spots.

    Diller L, Cherkerzian S, Cinelli AE, Housman D, Gillani R, Hamilton KV, Yeh JM, Bhattacharjee A, Parad RB

    Nature Communications 2026; 17(1).PubMed(opens in new window)
  • Clinical validation of an HPV whole-genome sequencing assay for MRD detection in patients with HPV+ head and neck cancer treated with surgery.

    Hirayama S, Al-Inaya Y, Bryan ME, Das D, Aye L, Naegele S, Mendel J, Faquin WC, Sadow PM, Crowson MG, Lin D, Varvares M, Feng AL, Deschler D, Paly J, Merkin R, Roberts TJ, Lawrence M, Iafrate AJ, Wirth L, Fisch AS, Guan Z, Richmon J, Faden DL

    Science Translational Medicine 2026; 18(853):eaec1724.PubMed(opens in new window)
  • Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: The CARES Pragmatic Cluster Randomized Clinical Trial.

    May FP, Brodney S, Tuan JJ, Syngal S, Chan AT, Glenn B, Johnson G, Chang Y, Drew DA, Moy B, Rodriguez NJ, Warner ET, Anyane-Yeboa A, Ukaegbu C, Davis AQ, Schoolcraft K, Regan S, Le Beaux K, Lee ET, Bhat R, Gordon A, Phan LK, Chirino AFC, Marotta CJ, Kindermann RGZ, Haas JS

    Jama Internal Medicine 2026.PubMed(opens in new window)
  • Circulating Tumor Cells Predict Response to the DLL3-targeting Bispecific Antibody Tarlatamab.

    Mishra A, Meador CB, Kikkeri K, Cunneely Q, Lin M, Carmona-LaSalle TJ, Huang SB, Bell R, Putaturo V, Xia W, Liang JH, Fang J, San Vicente S, Zielinski CE, Digumarthy SR, Hung YP, Yeap BY, Edd JF, Lawrence MS, Sade-Feldman M, Sen DR, Toner M, Maheswaran S, Gainor JF, Haber DA

    Cancer Discovery 2026.PubMed(opens in new window)
  • Geographic and Temporal Patterns of Screening for Breast, Cervical, and Colorectal Cancer in the US, 1997-2019.

    Pradhan P, Iyer HS, Rebbeck TR

    Jama Network Open 2025; 8(10):e2537905.PubMed(opens in new window)
  • The E3 ligase HECTD4 regulates COX-2-dependent tumor progression and metastasis.

    Vuille JA, Tanriover C, Antmen E, Micalizzi DS, Ebright RY, Animesh S, Morris R, Hajizadeh S, Nicholson ZJ, Russell HC, Zaniewski EF, Wittner BS, Wesley BK, Kwak JE, Grünewald J, Szalay RN, Fox DB, Yang M, Joung JK, Gulhan DC, Elia AEH, Haas W, Oh E, Maheswaran S, Haber DA

    Proceedings of the National Academy of Sciences of the United States of America 2025; 122(32):e2425621122.PubMed(opens in new window)
  • Early Postoperative Minimal Residual Disease Detection with MAESTRO Is Associated with Recurrence and Worse Survival in Patients with Head and Neck Cancer.

    Sim ES, Rhoades J, Xiong K, Walsh L, Crnjac A, Blewett T, Al-Inaya Y, Mendel J, Ruiz-Torres DA, Efthymiou V, Lumaj G, Benjamin WJ, Makrigiorgos GM, Tabrizi S, Adalsteinsson VA, Faden DL

    Clinical cancer research : an official journal of the American Association for Cancer Research 2025; OF1-OF9.PubMed(opens in new window)
  • A thin cryobiopsy device compatible with transnasal endoscopy for the gastrointestinal tract.

    Otuya DO, Farrokhi H, Verma Y, Dong J, Choy P, Kumar A, Shore RE, Zemlok SK, Sevieri E, Schellenberg M, Spicer G, Lopez DR, Osman HA, Gardecki JA, Kyrollos Kelada AAF, Gao AH, Chung A, Grant CN, Bhat NGM, Rosenberg M, Jacobson BC, Nishioka NS, Colson Y, Tearney GJ

    Science Translational Medicine 2025; 17(796):eado9609.PubMed(opens in new window)
  • Preventive Health Care Use Among Adults Eligible for Lung Cancer Screening in the US.

    Potter AL, Kothagundla S, Haridas C, Chang AEB, Sequist LV, Yang CJ

  • Cytisinicline for Smoking Cessation: The ORCA Phase 3 Replication Randomized Clinical Trial.

    Rigotti NA, Benowitz NL, Prochaska JJ, Rubinstein M, Clarke A, Blumenstein B, Cain DF, Jacobs C

    Jama Internal Medicine 2025.PubMed(opens in new window)
  • Economic Evaluation of Tobacco Treatments From the Screen ASSIST Lung Cancer Screening Trial.

    Levy DE, Hassan S, Wint AJ, Marotta C, Gonzalez I, Chang Y, Rigotti NA, Haas JS, Park ER

    Jama Network Open 2026; 9(1):e2555332.PubMed(opens in new window)

Cancer Risk, Prevention, and Early Detection Program Members

Members