Program

Breast Cancer Program

The mission of the Breast Cancer Program is to reduce morbidity and mortality from breast cancer through innovative basic and translational research and the conduct of impactful clinical trials.

The HCC Breast Users Committee and Resources for Research

The Breast Users Committee is the supervising body for use of the breast cancer data and/or specimens from the HCC. The members of the HCC Breast Users Committee are charged with reviewing the feasibility and scientific validity of proposed clinical and health services research, qualitative improvement (QI) projects, and translational and laboratory-based projects using the specimens and clinical data available through HCC breast cancer-focused research protocols.

 

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Recent, High-Impact Publications

  • Medical Therapy for Hormone Receptor-Positive, HER2-Negative Stage I-III Breast Cancer: ASCO Living Guideline, Version 2026.1.0.

    Caswell-Jin JL, Somerfield MR, Khan MA, Kimmick GG, Gupta S, Kenan K, Peswani N, Hershman DL, Ernst BJ, Harvey BE, Krings G, McAndrew NP, Riaz IB, Vaz-Luis I, Villarreal-Garza C, Oberoi JK, Sadiq MH, He H, Chitale R, Hassett MJ

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2026; 101200JCO2602034.PubMed(opens in new window)
  • Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4.

    Chu C, Zheng S, Mitchell N, Li Z, Zhang X, Wu X, Zhang T, Dang F, Michowski W, Kolodziejczyk A, Xu ML, Kotowski KW, Yang Z, Martinez-Alonso D, Paulo J, Sheng J, Kirby JA, Groezinger F, Zhou Y, He M, Ito Y, Gulvady AC, Cole MI, Foidart P, Nishida J, Ning X, Sharma S, Suski JM, Fassl A, Zhou Y, Geng Y, Wei W, Gygi SP, Polyak K, Wucherpfennig KW, Sicinski P

    Molecular cell 2026.PubMed(opens in new window)
  • Progression-Free Survival in Metastatic Breast Cancer by Local Investigators vs Blinded Independent Central Review: A Systematic Review and Meta-Analysis.

    Ravani LV, Bagheri Z, Kalinsky K, Burstein HJ, Bardia A, Mouabbi JA, O'Regan R, Wander SA

    Jama Oncology 2026.PubMed(opens in new window)
  • Neoadjuvant Paclitaxel, Trastuzumab, and Pertuzumab for Stage II to III, ERBB2-Positive Breast Cancer: A Secondary Analysis of the DAPHNe Trial.

    Tarantino P, Li T, Ogayo ER, Rahman T, DiLullo MK, Patel A, El-Refai S, Abbott C, Li B, Boyle SM, Chen RO, Desai NV, Spring LM, Tung NM, Sinclair N, Faggen M, Constantine M, King TA, Krop IE, Tayob N, Mittendorf EA, Tolaney SM, Winer EP, Parsons HA, Waks AG

    Jama Oncology 2026.PubMed(opens in new window)
  • Proteolysis activity mapping and substrate discovery platform for identifying tumor-activated biosensors.

    Algov I, Van Heest A, Hopton M, Liang F, Holmes A, Hao L, Zhou X

    Nature chemical biology 2026.PubMed(opens in new window)
  • Real-world effectiveness of palbociclib plus an aromatase inhibitor in HR+/HER2- MBC patients living in disadvantaged neighborhoods.

    Lynce F, Liu X, Li B, McRoy L, Chen C, Liu R, Rugo HS

    Npj Breast Cancer 2025; 11(1):75.PubMed(opens in new window)
  • Carboplatin with or without nivolumab in metastatic triple-negative breast cancer: a randomized phase II trial.

    Garrido-Castro AC, Graham N, Li KX, Bi L, Crowdis J, Bi K, Park J, Pastorello R, Li Y, Gupta H, Kuntz T, Petry R, Pasquina LW, Patel A, Lange P, DiLullo M, Attaya V, Frey AM, Childress MA, Wesolowski R, Sinclair N, Sinclair S, Lo S, Tung N, Faggen M, Kaufman PA, Block CC, Walsh J, Toke M, Chen W, Wucherpfennig KW, Tian Y, Williams AJ, Mukhopadhyay S, Dasgupta T, Schnitt S, Cherniack AD, Barroso R, Ligibel J, Lin NU, Mittendorf EA, Tayob N, Van Allen E, Tolaney SM

    Nature Communications 2026.PubMed(opens in new window)
  • Targeting FGFR signaling overcomes therapeutic resistance and immune evasion in oncogenic PIK3CA-driven serous-like endometrial cancer.

    Cheng X, Zhang Y, Qian C, Holdridge E, Ananda G, Jiang T, Ni J, Xie S, Gu H, Ji R, Ivanova EV, Nucci MR, Wang Z, Chen K, Kochupurakkal B, Freeman GJ, Shapiro GI, Liu J, Konstantinopoulos PA, Matulonis U, Zhao JJ

    Nature Communications 2026.PubMed(opens in new window)
  • Extended Endocrine Therapy and Survival for Breast Cancer Subtypes in Premenopausal Patients.

    Valenza C, Zheng Y, Milano M, Berton Giachetti PPM, Trapani D, Giordano E, Guidi L, Boldrini L, Castellano G, Katrini J, Malagutti B, Antonarelli G, Etessami JD, Bianco N, Conforti F, Kirkner GJ, Sangalli C, Dibble KE, Fusco N, Colleoni M, Regan MM, Munzone E, Curigliano G, Partridge AH

    Jama Network Open 2026; 9(5):e2610427.PubMed(opens in new window)
  • Updated Results of the POSITIVE (Pregnancy Outcome and Safety of Interrupting Therapy for Women with Endocrine Responsive Breast Cancer) Trial.

    Pagani O, Niman SM, Ruggeri M, Peccatori FA, Azim HA, Colleoni M, Saura C, Shimizu C, Sætersdal AB, Kroep JR, Warner E, Amant F, Mailliez A, Moore HCF, Ruiz-Borrego M, Walshe JM, Borges VF, Gombos A, Kataoka A, Rousset-Jablonski C, Borstnar S, Takei J, Lee JE, Saunders C, Bjelic-Radisic V, Susnjar S, Cardoso F, Klar NJ, Ferreiro T, Ribi K, Ruddy KJ, Kammler R, El-Abed S, Viale G, Piccart M, Korde LA, Goldhirsch A, Gelber RD, Partridge AH, ,

    Annals Of Oncology : Official Journal Of The European Society For Medical Oncology 2026.PubMed(opens in new window)
  • Healthy Lifestyle Advice and Practice Among Cancer Survivors in the US.

    Cao C, Schmitz KH, Giovannucci EL, Lee IM, Partridge AH, Ligibel JA

    Jama Oncology 2026.PubMed(opens in new window)
  • Survival and Treatment Patterns in Stage III Inflammatory and Noninflammatory Breast Cancer.

    Leone JP, Leone J, De Placido P, Nakhlis F, Schlam I, Hirko KA, Hazra A, Troll E, Bellon JR, Vallejo CT, Lin NU, Tolaney SM, Lynce F

    Jama Network Open 2026; 9(4):e265014.PubMed(opens in new window)

Breast Cancer Program Members

Leaders

Members