Analysing long-read CRISPR experiments with CRISPRLungo.
Hwang GH, Vyshedskiy B, Barry T, Zeng J, Levesque S, Manis JP, Shimamura A, Bauer DE, Pinello L
Changes in the transcriptome and synthetic lethal dependencies following mutant expression reveal profound tissue specificity.
Martin TD, Choi MY, McBride JC, Elledge SJ
Automated prototyping of genetic codes.
Radford F, Sapers N, Burgess HM, Ort L, Budnik B, Church GM
LINE-1 insertion intermediates recombine with one another or with DNA breaks to form genome rearrangements.
Mendez-Dorantes C, Kalinowski JC, Burn A, Schofield P, Law CT, Isik E, Burns KH
Conserved neuronal-like and secretory programs define the spatial architecture of gastroenteropancreatic neuroendocrine tumors.
Karam J, Hoffman SE, Garza A, Gui D, Hoffman HI, Titchen BM, Tanaka Y, Pimenta E, Pappa T, Valderrabano L, Bi K, Gillani R, Brais L, Shannon E, Hornick JL, Park J, Chan J, Van Allen EM
Virome-wide ubiquitin ligase discovery reveals diverse mechanisms of immune evasion.
Glassman CR, Baek K, Hou G, Zeng Q, Nardone C, Juergens KB, Fujimura E, O'Leary CN, Li MZ, Paulo JA, Fischer ES, Ding S, Harper JW, Elledge SJ
A compendium of next-generation patient-derived models for diverse cancers.
ElHarouni D, Al-Jazrawe M, Choi S, Dede M, Hinoue T, Misek SA, Noh H, Zanella L, Tseng YY, Francies HE, Plenker D, Kyi CW, Perez-Mayoral J, Stine MJ, Tonsing-Carter E, Agarwal R, Zenklusen JC, Clinton JM, Shelton JM, Chu TR, Hooper WF, Loinaz X, Keskula P, Tagle J, Kuhlers PC, Tercan B, Boj SF, Vasciaveo A, Tomassoni L, Crawford JM, Walsh S, Sinai C, Bhatia S, Sridevi P, Patel H, Cerone MA, , Ellrott K, Kuo CJ, Elemento O, Beyaz S, Corbo V, Spector DL, Beroukhim R, Ferguson ML, Cherniack AD, Laird PW, Robine N, McPherson A, Hoadley KA, Garnett MJ, Tuveson DA, Califano A, Spellman PT, Ligon KL, Gerhard DS, Staudt LM, Boehm JS
A Bayesian framework for longitudinal EHR and genetic discovery.
Urbut SM, Ding Y, Nakao T, Koyama S, Misra A, Jiang X, Harish A, Gaffney L, Hornsby WE, Smoller JW, Gusev A, Natarajan P, Parmigiani G
Chromatin topology and distal elements underlie divergent cell-type-specific regulation of 9p21 locus cell cycle genes.
Torlai Triglia E, Miller TE, Durand NC, Kim KL, Casaní-Galdón S, D'Antonio J, Javed N, Paz Hernandez A, Raman A, Cruz AJ, Issner R, Choudhary A, Aguet F, Verga J, Chan M, Ramanathan V, Li CM, Hecht V, Hansen AS, Aryee MJ, Epstein CB, Kelley DR, Najm FJ, Shoresh N, Ardlie K, Hendrickson DG, Ruby JG, Bernstein BE, Gaskell E
A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.
Fujimura E, O'Leary CN, Li MZ, Roberts RA, Glassman CR, Paulo JA, Jiang H, Abdelfattah NS, Wooten EC, Mirman Z, Harper JW, Cole PA, Elledge SJ
SIRT7 regulates dosage compensation and safeguards the female X chromosome.
Simonet NG, Thackray JK, Kesner B, Guitart-Solanes A, Serra F, Espinosa-Alcantud M, Lappala A, Marín-Gual L, Marín-García C, Weissbein U, Castelló-García J, Bauer M, Wang D, Rovirosa L, Tischfield J, Serrano L, Payer B, Ruiz-Herrera A, Vazquez BN, Javierre BM, Vaquero A, Lee JT
SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues.
Jia Y, Sun D, Weir JA, Liu X, Russell AJC, Kim Y, Thom N, Marrero G, Kumar V, Chen F, Camargo FD
