Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.
Shettigar M, Moulière S, Isenegger L, DeVine AL, Gstalder C, Koduri V, Doench JG, Ksander B, Garcia-Marcos M, Kaelin WG, Haq R
Enfortumab Vedotin-Induced Cutaneous Toxic Effects and Survival in Urothelial Carcinoma.
Lee E, Karagenova R, Lu C, Farokh P, Azin M, Repetto F, Jobbagy S, Nazarian RM, Reynolds K, Demehri S, Saylor PJ, Fuksman L, Semenov YR
Cost-Effectiveness of Oral Nicotinamide for Keratinocyte Carcinoma Prevention.
Perez D, Breglio KF, Knox KM, Pereira AC, Gaziano JM, Wheless LE, Hartman RI
Recurrent ZC3H18 mutations stabilize oncogenic endogenous retroviral RNA.
Tanu T, Cox AM, Karlow JA, Sharma P, Sun K, He X, Babu S, Roelofs MK, Jeon E, Chen J, Wu C, Brown J, Barrientos NB, McCallion AS, Brown KM, Chanock SJ, Liu D, Zhang T, Burns KH, Boutz PL, Insco ML
Multimodal blood based proteomic profiling reveals insights into mechanisms of immunotherapy resistance.
Wright SJ, Zamora I, Parikh M, Yeramosu D, Rucevic M, Sade-Feldman M, LaSalle TJ, Blaum EM, Liu B, Bi L, Kang S, Blum SM, Nguyen N, Guess J, Kar A, Schneider AM, Lieb D, Woods E, Michaud W, Lawless AR, Sharova T, Cohen S, Kasumova G, Kim MS, Cheng LC, Villani AC, Park RJ, Jenkins RW, Klempner SJ, Sullivan RJ, Flaherty KT, Hacohen N, Mehta A, Boland GM
Lipid Nanoparticle-encapsulated mRNA-2752 Encoding Human OX40L, IL-23, and IL-36γ Plus Durvalumab Induces an Immunostimulatory Effect Within the Tumor Microenvironment in Patients with Advanced Solid Tumors.
Sweis RF, Long GV, Daud A, Stemmer SM, Jimeno A, Perets R, Kummar S, Patel MR, Khattak A, Abadier M, Van L, Guo R, Do KT, Sullivan RJ
Systemic Glucocorticoid Immunosuppression and Survival Among Immune Checkpoint Inhibitor Recipients.
Wan G, Nguyen N, Lu C, Khattab S, Yan B, Amadife M, Leung BW, Chen W, Rajeh A, Tang K, Thang C, Boland G, Reynolds KL, Yu KH, Gusev A, LeBoeuf NR, Kwatra SG, Semenov YR
A longitudinal, multi-omic atlas reveals the emergence of a spatially organized immunosuppressive ecosystem in resistant melanoma.
Wei S, Deng Y, Lee J, Lan H, Yang Z, Labrie M, Betts CB, Duan H, Tate B, Pucilowska J, Frederick D, Lawless AR, Sharova T, Yang Y, Hu W, Beasley GM, Schuchter LM, Wang X, Xu W, Yong G, Vandenberg MEG, Torigian DA, Sivagnanam S, Du K, Sugarman E, McGettigan S, Zheng C, Al-Rohil RN, Selim MA, Datto MB, López GY, Nair SK, Ashley DM, Xu X, Amaravadi RK, Karakousis GC, O'Rourke DM, Brem S, O'Malley BW, Demirkan G, Yu S, Lu Y, Camp T, Patterson JA, Wei Z, Corless C, Gabrilovich DI, Mou Y, Flaherty KT, Coussens LM, Boland G, Herlyn M, Mills G, Liu L, Zhang G
Lymph node environment drives FSP1 targetability in metastasizing melanoma.
Palma M, Chaufan M, Breuer CB, Müller S, Sabatier M, Fraser CS, Szylo KJ, Yavari M, Carmona A, Kaur M, Melo LMN, Cansiz F, Monge-Lorenzo J, Flores M, Mishima E, Nakamura T, Proneth B, Labrado M, Liang Y, Cayting N, Zheng L, Cañeque T, Colombeau L, Wahida A, Friedmann Angeli JP, Tasdogan A, Hui S, Rodriguez R, Conrad M, Reticker-Flynn NE, Ubellacker JM
CRATER tumor niches facilitate CD8 T cell engagement and correspond with immunotherapy success.
Ludin A, Stirtz GL, Tal A, Nirmal AJ, Pfaff KL, Manos M, Besson N, Eskndir N, Porter B, Jones SM, Faulkner HM, Gong Q, Liu S, Barrera I, Wu L, Pessoa Rodrigues C, Sahu A, Jerison E, Alessi JV, Ricciuti B, Richardson DS, Weiss JD, Moreau HM, Stanhope ME, Afeyan AB, Sefton J, McCall WD, Formato E, Yang S, Zhou Y, Hoytema van Konijnenburg DP, Cole HL, Cordova M, Deng L, Rajadhyaksha M, Quake SR, Awad MM, Chen F, Wucherpfennig KW, Sorger PK, Hodi FS, Rodig SJ, Murphy GF, Zon LI
Specific oncogene activation of the cell of origin in mucosal melanoma.
Babu S, Chen J, Baron CS, Sun K, Robitschek E, McConnell AM, Wu C, Dedeilia A, Sade-Feldman M, Modhurima R, Manos MP, Chen KY, Cox AM, Ludwig CG, Kellis M, Buchbinder EI, Hacohen N, Yang J, Boland GM, Abraham BJ, Liu D, Zon LI, Insco ML
A multi-adjuvant personal neoantigen vaccine generates potent immunity in melanoma.
Blass E, Keskin DB, Tu CR, Forman C, Vanasse A, Sax HE, Shim B, Chea V, Kim N, Carulli I, Southard J, Lyu H, Lu W, Rickles-Young M, Afeyan AB, Olive O, Mehndiratta A, Greenslade H, Shetty K, Baginska J, Gomez Diaz I, Nau A, Pfaff KL, Gans A, Ranasinghe S, Buchbinder EI, Sussman TA, Insco ML, Yoon CH, Rodig SJ, Shukla SA, Li S, Aster JC, Braun DA, Cibulskis C, Hacohen N, Neuberg DS, Giobbie-Hurder A, Livak KJ, Fritsch EF, Oliveira G, Simon JM, Wu CJ, Ott PA
