Matthew G. Oser, MD, PhD

Dana-Farber Cancer Institute

Academic Titles

Associate Professor, Medicine, Harvard Medical School

Research Program Affiliation

Member, Lung Cancer

Member, Cancer Genetics and Epigenetics

Research Abstract

The goal of my research is to identify new therapeutic targets in small cell lung cancer (SCLC) with the ultimate goal of bringing novel therapies to the clinic for SCLC patients. My focus is to use Cas9/CRISPR screening approaches to identify novel candidate therapeutic targets in SCLC that are a consequence of pRB loss, NOTCH inactivation, and dependencies that alter SCLCs neuroendocrine differentiation state. I then study these new candidate target genes in vivo using a novel immunocompetent genetically-engineered mouse model (GEMM) of SCLC that I developed using CRISPR.