Myles Brown, MD

Dana-Farber Cancer Institute

Academic Titles

Emil Frei III Professor of Medicine, Medicine, Harvard Medical School

Research Program Affiliation

Member, Prostate Cancer

Member, Breast Cancer

Research Abstract

Dr. Brown's research laboratory focuses on elucidating the epigenetic factors underlying the action of steroid hormones. This work has important implications both for normal physiology and for the treatment of hormone dependent malignancies including breast and prostate cancer. He is recognized for three seminal discoveries. His lab opened the steroid receptor coregulator field, illuminated the dynamic nature of receptor and coregulator interaction with the genome and elucidated the importance of epigenetically determined distant cis-regulatory steroid receptor binding sites. His contributions have uniquely reformulated the understanding of steroid hormone action in normal physiology and in hormone-dependent cancer.