Raymond H. Mak, MD

Brigham And Women's Hospital

Academic Titles

Associate Professor, Radiation Oncology, Harvard Medical School

Research Program Affiliation

Member, Lung Cancer

Research Abstract

My research interests include developing clinically-applicable genetic predictors of radiation response for radiation therapy in lung cancer, with a focus on both tumor radiosensitivity based on tumor genotype (e.g. by KRAS and EGFR mutations in non-small cell lung cancer) and germline genetic analysis for prediction of increased risk of radiation-induced normal tissue toxicity. Combining these two approaches will allow for an integrated “personalized” radiation therapy approach with a goal of widening the therapeutic window: both increasing the probability of tumor control while reducing the risk of radiation-induced injury.