Himisha Beltran, MD

Dana-Farber Cancer Institute

Academic Titles

Professor, Medicine, Harvard Medical School

Research Program Affiliation

Member, Prostate Cancer

Research Abstract

My lab is focused on understanding mechanisms of treatment resistance in advanced prostate cancer through the integration of clinical and molecular features of patients combined with preclinical modeling. We have focused on understanding an emerging subclass of androgen-indifferent prostate cancers that develop neuroendocrine features as a mechanism of lineage plasticity upon selective therapeutic pressure of the androgen receptor (AR). We have used genomics and epigenomics to elucidate the molecular mechanisms driving evolution towards an AR-low state. We are developing tissue and circulating biomarkers and novel therapeutic strategies for clinical translation. Our mission is to make discoveries that improve the way we manage and treat patients with advanced prostate cancer.