Raif S. Geha, MD

Boston Children's Hospital

Academic Titles

James L. Gamble Professor, Pediatrics, Harvard Medical School

Research Program Affiliation

Member, Cancer Immunology

Research Abstract

I have been studying primary immunodeficiency disease for almost 40 years. I have extensive experience in the characterization of PIDs including examination of molecular aspects and signal transduction pathways and have developed a number of transgenic mouse models of PIDs. I have also described a number of genes the mutations of which cause or contribute to PIDs. As Immunology Division Chief at Children’s I am responsible for overseeing both the clinical care and research on patients with primary immunodeficiency. In this function, I see many patients with immunodeficiency syndromes of unclear etiology. I have also trained a large number of now independent investigators in the PID field. Many PIDS are associated with auto-immunity and cancer in lymphoid and non lymphoid tissues I am interested in investigation the mechanisms by which PIDs lead to these 2 complications