Roy B. Tishler, MD, PhD

Dana-Farber Cancer Institute

Academic Titles

Associate Professor, Radiation Oncology, Harvard Medical School

Research Program Affiliation

Member, Head and Neck Cancer

Research Abstract

My laboratory research focuses on the molecular mechanisms of interaction of radiation and chemotherapeutic drugs, particularly the taxanes. Current projects are examining the role of the tumor suppressor p53 and bcl-2 related proteins on the interaction of Taxol and radiation in human tumor cells. We are also examining other chemotherapy-radiaton interactions, as well as different aspects of radiation-dependent gene induction. My clinical reasearch interests are: 1) use of combined modality treatment for organ preservation in the treatment of head and neck cancers 2) role of radiation sensitizers and chemotherapeutic drugs in treatment of tumors of the central nervous system.